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mitotane will lower the extent or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites.Cell proliferation was assessed using a bromodeoxyuridine (BrdU) proliferation assay